Liquid crystal (LC) has a unique phase of matter with high birefringence and mobility. This novel phase provides extreme sensitivity to the surface events such as adsorption, ligand-receptor interactions, enzymatic reactions, etc. in the development of biosensors. Our group established the method for fabricating LC-based biosensors for detecting important biomaterials (such as glucose, urea, cholesterol, proteins, DNA, etc.) both qualitatively and quantitatively through a polarized optical microscope.